Which list contains examples of high immunogenicity viruses?

• A. Rabies, Parvovirus, Panleukopenia
• B. HIV, Hepatitis B, Rotavirus
• C. Coronavirus, Adenovirus, Rhinovirus
• D. Measles, Varicella, Dengue

Answer: (A)

Immunogenicity refers to a virus’s ability to provoke a robust immune response, including strong antibody production and durable memory. Rabies virus is known for eliciting a rapid and potent neutralizing antibody response, which is why vaccination after exposure is highly protective. Parvoviruses, including those that cause feline panleukopenia and canine/parvovirus diseases, have highly antigenic capsids that stimulate strong humoral immunity. Together, these examples illustrate viruses that consistently provoke strong immune responses.

The other groups contain viruses with more variable or weaker immunogenic profiles in typical discussions: HIV is notorious for evading the immune system and not generating protective immunity easily; Dengue has complex immune dynamics with antibody-dependent enhancement and serotype interactions; Rhinovirus often produces only transient or less durable responses; Adenovirus and Coronavirus can be immunogenic but are not universally described as the strongest in terms of durable, protective immunity. Therefore, the set with Rabies, Parvovirus, and Panleukopenia best represents high immunogenicity viruses.